{"product_id":"recombinant-murine-interleukin-6-rmuil-6-pr2026","title":"Recombinant Murine Interleukin-6 (rMuIL-6) - PR2026","description":"\u003cp\u003eRecombinant Murine Interleukin-6 (rMuIL-6)\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PR2026-2, PR2026-10\u003c\/p\u003e\n\n\u003cp\u003eSizes: 2µg, 10µg\u003c\/p\u003e\n\n\u003cp\u003eSource: Escherichia coli\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: Approximately 21.7 kDa, a single non-glycosylated polypeptide chain containing 187 amino acids\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt;97% by SDS-PAGE and HPLC analyses.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is \u0026lt; 0.02 ng\/ml, corresponding to a specific activity of \u0026gt; 5 x 107 units\/mg\u003c\/p\u003e\n\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: FPTSQVRRGD FTEDTTPNRP VYTTSQVGGL ITHVLWEIVE MRKELCNGNS\u003cbr\u003e\n DCMNNDDALA ENNLKLPEIQ RNDGCYQTGY NQEICLLKIS SGLLEYHSYL\u003cbr\u003e\n EYMKNNLKDN KKDKARVLQR DTETLIHIFN QEVKDLHKIV LPTPISNALL\u003cbr\u003e\n TDKLESQKEW LRTKTIQFIL KSLEEFLKVT LRSTRQT\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Less than 1EU\/mg of rMuIL-6 as determined by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg\/ml. Stock solutions should be apportioned into working aliquots and stored at \u0026lt;-20°C. Further dilutions should be made in appropriate buffered solutions.\u003c\/p\u003e\n\n\u003cp\u003eStorage: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze\/thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China\u003c\/p\u003e\n\n\u003cp\u003eDescription: Interleukin 6 is a multi functional protein that plays important roles in host defense, acute phase reactions, immune responses, and hematopoiesis. IL-6 is expressed by a variety of normal and transformed cells including T cells, B cells, monocytes\/macrophages, fibroblasts, hepatocytes, keratinocytes, astrocytes, vascular endothelial cells, and various tumor cells. The production of IL-6 is upregulated by numerous signals including mitogenic or antigenic stimulation, LPS, calcium ionophore, IL-1, IL-2, IFN, TNF, PDGF, and viruses. IL-6 expression in monocytes is inhibited by IL-4 and IL-13.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"2µg","offer_id":42882222227635,"sku":"PR2026-2","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"10µg","offer_id":42882222260403,"sku":"PR2026-10","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e8fb70dd-12b9-47ab-a63f-300d74b68d47.jpg?v=1702049538","url":"https:\/\/afsbio.com\/products\/recombinant-murine-interleukin-6-rmuil-6-pr2026","provider":"AFSBio Inc.","version":"1.0","type":"link"}