{"product_id":"recombinant-osm-mouse-bk0148","title":"Recombinant OSM, Mouse - BK0148","description":"\u003cp\u003eRecombinant OSM, Mouse\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BK0148-10, BK0148-50\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eSource: Escherichia coli\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 20.5 kDa, observed by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95% as analyzed by SDS-PAGE and HPLC.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: ED50 \u0026lt; 10 ng\/mL, measured by a cell proliferation assay using Rat Embryo Brain cells, corresponding to a specific activity of \u0026gt; 1× 10ˆ5 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized after extensive dialysis against PBS.\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: MNRGCSNSS SQLLSQLQNQ ANLTGNTESL LEPYIRLQNL NTPDLRAACT QHSVAFPSED TLRQLSKPHF LSt VYTTLDR VLYQLDALRQ KFLKTPAFPK \u003cbr\u003e\n LDSARHNILG IRNNVFCMAR LLNHSLEIPE PTQTDSGASR STTTPDVFNT KIGSCGFLWG YHRFMGSVGR VFREWDDGST RSR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.2 EU\/μg, determined by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Reconstituted in ddH2O or PBS at 100 μg\/ml.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Lyophilized recombinant Mouse Oncostatin M (rmOSM) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmOSM remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.\u003c\/p\u003e\n\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor β or LIF Receptor β to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant Mouse Oncostatin M (rmOSM) produced in E.coli is a single non-glycosylated polypeptide chain containing 182 amino acids. A fully biologically active molecule, rmOSM has a molecular mass of 20.5 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"10μg","offer_id":42882245787827,"sku":"BK0148-10","price":375.54,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":42882245820595,"sku":"BK0148-50","price":1152.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_2cc8ebae-fb95-4fbb-bfb4-0bbcb46bb817.jpg?v=1702049987","url":"https:\/\/afsbio.com\/products\/recombinant-osm-mouse-bk0148","provider":"AFSBio Inc.","version":"1.0","type":"link"}