{"product_id":"recombinant-rabbit-b7-1-cd80-protein-his-tag-pksq050068","title":"Recombinant Rabbit B7-1\/CD80 Protein (His Tag) - PKSQ050068","description":"\u003cp\u003eRecombinant Rabbit B7-1\/CD80 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSQ050068-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Rabbit B7-1; CD80\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P42070\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P42070\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1\/CD80 and B7-2\/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gly33-Gln241\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 24.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 30-50 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43072230031539,"sku":"PKSQ050068-50","price":155.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_58c7838d-e574-449f-972f-fe0e21a666b2.png?v=1708684717","url":"https:\/\/afsbio.com\/products\/recombinant-rabbit-b7-1-cd80-protein-his-tag-pksq050068","provider":"AFSBio Inc.","version":"1.0","type":"link"}