{"product_id":"recombinant-rat-aif-m1-protein-his-tag-pder100061","title":"Recombinant Rat AIF-M1 protein (His tag) - PDER100061","description":"\u003cp\u003eRecombinant Rat AIF-M1 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDER100061-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: AIF-M1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: AIFM1; Apoptosis inducing factor 1; mitochondrial; Apoptosis inducing factor; CMTX4; COWCK; COXPD6; Harlequin; mitochondrial; PDCD 8; Programmed cell death 8; Striatal apoptosis inducing factor\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9JM53\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology; Epigenetics and Nuclear Signaling; Cancer; Metabolism; Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Rat\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9JM53\u003c\/p\u003e\n\n\u003cp\u003eBackground: Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Arg 150-Val 299\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 16.39 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 18 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083603902643,"sku":"PDER100061-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d4d8bcd0-7208-4ce0-ac99-7cb7a9e3f10f.png?v=1708945063","url":"https:\/\/afsbio.com\/products\/recombinant-rat-aif-m1-protein-his-tag-pder100061","provider":"AFSBio Inc.","version":"1.0","type":"link"}