{"product_id":"recombinant-rat-alk-1-acvrl1-protein-rp01925","title":"Recombinant Rat ALK-1\/ACVRL1 Protein - RP01925","description":"\u003cp\u003eRecombinant Rat ALK-1\/ACVRL1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01925-10, RP01925-20, RP01925-50, RP01925-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Recombinant Rat ALK-1\/ACVRL1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys21-Ala118) of Rat ALK-1\/ACVRL1 (Accession #NP_071886.1) fused with a hFc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Acvrl1, Acvrlk1, Serine\/threonine-protein kinase receptor R3, SKR3, 2.7.11.30, TGF-B superfamily receptor type I, TSR-I\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P80203\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 25237\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Rat\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: ALK-1\/ACVRL1,Type I receptor for TGF-beta family ligands BMP9\/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine\/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat ALK-1(Catalog #RP01925) at 4 μg\/mL (100 μL\/well) can bind Human ACVR2B (Catalog #RP00153) with a linear range of 20-989.42 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: KGDLVKPSRGQLVNCTCENPHCKRPICQGAWCTVVLVREQGRHPQVYRGCGSLNQELCLGRPTEFVNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDA\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198348681395,"sku":"RP01925-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198348714163,"sku":"RP01925-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198348746931,"sku":"RP01925-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198348779699,"sku":"RP01925-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_f752a36c-69ea-4b4c-a7d7-901890c8d08c.png?v=1766960891","url":"https:\/\/afsbio.com\/products\/recombinant-rat-alk-1-acvrl1-protein-rp01925","provider":"AFSBio Inc.","version":"1.0","type":"link"}