{"product_id":"recombinant-rat-angiotensinogen-agt-protein-his-tag-pdmr100022","title":"Recombinant Rat Angiotensinogen\/AGT protein (His tag) - PDMR100022","description":"Recombinant Rat Angiotensinogen\/AGT protein (His tag)\n\nSizes: 20μg, 100μg\n\nCatalogue Numbers: PDMR100022-20, PDMR100022-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: Angiotensinogen; AGT\n\nTarget Synonym: Angiotensinogen; Serpin A8; Agt; Serpina8\n\nUNIProt ID: P01015\n\nResearch Areas: Cardiovascular\n\nTarget Species: Rat\n\nExpression Host: HEK293 Cells\n\nFusion Tag: C-His\n\nAccession: P01015\n\nBackground: Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α -2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. Angiotensinogen can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Angiotensinogen\/AGT and its renin-cleaved product, des(Ang I)AGT, are angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma. The Angiotensinogen products, that is angiotensin II and possibly angiotensin II-related products, have been found to act locally in modulating adipose tissue growth in an autocrine\/paracrine manner.\n\nSequence: Met1-Val477\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4.\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: Please contact us for more information.\n\nCalculated MW: 52.36 kDa\n\nObserved MW: 60 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43083636670643,"sku":"PDMR100022-20","price":418.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43083636703411,"sku":"PDMR100022-100","price":698.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ddf81f33-bed3-4927-8950-827761f04b38.png?v=1708945752","url":"https:\/\/afsbio.com\/products\/recombinant-rat-angiotensinogen-agt-protein-his-tag-pdmr100022","provider":"AFSBio Inc.","version":"1.0","type":"link"}