{"product_id":"recombinant-rat-egfr-erbb1-protein-his-tagactive-pksr030363","title":"Recombinant Rat EGFR\/ErbB1 Protein (His Tag)(Active) - PKSR030363","description":"Recombinant Rat EGFR\/ErbB1 Protein (His Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSR030363-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: EGFR; ErbB1\n\nTarget Symptom: EGFR\n\nTarget Species: Rat\n\nExpression Host: HEK293 Cells\n\nApplication: ELISA\n\nFusion Tag: C-His\n\nUNIProt ID: E7CXR8\n\nAccession: E7CXR8\n\nBackground: As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α , betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K\/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.\n\nActivity: Measured by its ability to bind recombinant human EGF-Fc and mouse EGF-Fc in functional ELISA.\n\nSequence: Met1-Ser646\n\nPurity: \u0026gt; 98 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: Please contact us for more information.\n\nCalculated MW: 70.7 kDa\n\nObserved MW: 93-110 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107246145715,"sku":"PKSR030363-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_1e5c0877-7d8d-4a9f-8062-cb58d84b3b81.png?v=1709381884","url":"https:\/\/afsbio.com\/products\/recombinant-rat-egfr-erbb1-protein-his-tagactive-pksr030363","provider":"AFSBio Inc.","version":"1.0","type":"link"}