{"product_id":"recombinant-rat-il-4-protein-rp01874","title":"Recombinant Rat IL-4 Protein - RP01874","description":"\u003cp\u003eRecombinant Rat IL-4 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01874-10, RP01874-20, RP01874-50, RP01874-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Rat IL-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys25-Ser147) of Rat IL-4 (Accession #NP_958427.1) fused with a His at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: B-cell growth factor 1; B-cell IGG differentiation factor; B-cell stimulatory factor 1; BSF-1; H-IL-4; IL-4; ILN; Interleukin; Interleukin-4; Interleukin4; Lymphocyte stimulatory factor 1; M-IL-4; MGC79402\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P20096\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 287287\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Rat\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90% as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured in a cell proliferation assay using TF-1 Human erythroleukemic cells. The ED50 for this effect is 0.65-2.6 μg\/mL, corresponding to a specific activity of 3.85×10^2 ~1.54×10^3 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: CNDSPLREIINTLNQVTEKGTPCTEMFVPDVLTATRNTTENELICRASRVLRKFYFPRDVPPCLKNKSGVLGELRKLCRGVSGLNSLRSCTVNESTLTTLKDFLESLKSILRGKYLQSCTSMS\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198339768499,"sku":"RP01874-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198339801267,"sku":"RP01874-20","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198339834035,"sku":"RP01874-50","price":490.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198339866803,"sku":"RP01874-100","price":784.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_610a0d91-1708-496d-a1a6-91d4d9edc672.png?v=1766960786","url":"https:\/\/afsbio.com\/products\/recombinant-rat-il-4-protein-rp01874","provider":"AFSBio Inc.","version":"1.0","type":"link"}