{"product_id":"recombinant-rat-il-6-interleukin-6-protein-active-pksr030420","title":"Recombinant Rat IL-6\/Interleukin-6 Protein (Active) - PKSR030420","description":"Recombinant Rat IL-6\/Interleukin-6 Protein (Active)\n\nSizes: 20μg, 100μg\n\nCatalogue Numbers: PKSR030420-20, PKSR030420-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: IL-6; Interleukin-6\n\nTarget Symptom: IL6\n\nTarget Species: Rat\n\nExpression Host: E.coli\n\nApplication: Cell culture\n\nFusion Tag: None\n\nAccession: NP_036721.1\n\nBackground: Interleukin-6 (IL-6) is a multifunctional α -helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine\/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.\n\nActivity: Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 1-6 ng\/ml.\n\nSequence: Phe25-Thr211\n\nPurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile 40% acetonitrile, 0.1% TFA\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: Please contact us for more information.\n\nCalculated MW: 21.9 kDa\n\nObserved MW: 22 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43114022240435,"sku":"PKSR030420-20","price":508.2,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43114022273203,"sku":"PKSR030420-100","price":1660.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c87baeaf-f9a1-4070-93b0-f8d796c5bacf.png?v=1709550361","url":"https:\/\/afsbio.com\/products\/recombinant-rat-il-6-interleukin-6-protein-active-pksr030420","provider":"AFSBio Inc.","version":"1.0","type":"link"}