{"product_id":"recombinant-rat-interleukin-12-subunit-beta-il-12b-protein-his-tag-pdmr100029","title":"Recombinant Rat Interleukin-12 subunit beta\/IL-12B protein (His tag) - PDMR100029","description":"\u003cp\u003eRecombinant Rat Interleukin-12 subunit beta\/IL-12B protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDMR100029-20, PDMR100029-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL-12B\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Interleukin-12 subunit beta; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; Il12b; rCG_35081\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: E9PU71\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; epigenetics and nuclear signal; immunology;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Rat\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: E9PU71\u003c\/p\u003e\n\n\u003cp\u003eBackground: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK\/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met1-Ser335\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 36.74 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 42 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43083637555379,"sku":"PDMR100029-20","price":502.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43083637588147,"sku":"PDMR100029-100","price":838.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_eda1f297-1898-44ca-b802-78f419c2cbd1.png?v=1708945775","url":"https:\/\/afsbio.com\/products\/recombinant-rat-interleukin-12-subunit-beta-il-12b-protein-his-tag-pdmr100029","provider":"AFSBio Inc.","version":"1.0","type":"link"}