{"product_id":"recombinant-rat-sclerostin-sost-protein-rp01583","title":"Recombinant Rat Sclerostin\/SOST Protein - RP01583","description":"\u003cp\u003eRecombinant Rat Sclerostin\/SOST Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01583-10, RP01583-20, RP01583-50, RP01583-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Rat Sclerostin\/SOST Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe29-Tyr213) of rat Sclerostin\/SOST (Accession #NP_085073.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: sclerostin, SOST, VBCH, SOST\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q99P67\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 80722\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Rat\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: FKNDATEIIPGLREYPEPPQELENNQTMNRAENGGRPPHHPYDTKDVSEYSCRELHYTRFVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRVKWWRPNGPDFRCIPDRYRAQRVQLLCPGGAAPRSRKVRLVASCKCKRLTRFHNQSELKDFGPETARPQKGRKPRPRARGAKANQAELENAY\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198241202355,"sku":"RP01583-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198241235123,"sku":"RP01583-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198241267891,"sku":"RP01583-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198241300659,"sku":"RP01583-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_2a3dbae8-5c41-4e19-b60a-4cf9d05ffa5f.png?v=1766959618","url":"https:\/\/afsbio.com\/products\/recombinant-rat-sclerostin-sost-protein-rp01583","provider":"AFSBio Inc.","version":"1.0","type":"link"}