{"product_id":"recombinant-rat-tgfbr1-protein-his-tag-pder100074","title":"Recombinant Rat TGFBR1 protein (His tag) - PDER100074","description":"\u003cp\u003eRecombinant Rat TGFBR1 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDER100074-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TGFBR1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: AAT5; Activin receptor like kinase 5; ACVRLK4; ALK-5; LDS1A; LDS2A; MSSE; SKR4; TbetaR I; TGF-beta receptor type-1; TGFBR1; Transforming growth factor beta receptor 1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P80204\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular; Signal Transduction; Stem Cells; Cancer; Metabolism; Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Rat\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P80204\u003c\/p\u003e\n\n\u003cp\u003eBackground: Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine\/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor, originally known as ALK-5 (Activin receptor-like kinase) is also a membrane-bound serine\/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu 311-Met 501\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 20.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 28 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083605115059,"sku":"PDER100074-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0db0b787-0222-445d-92c5-8847003608e0.png?v=1708945088","url":"https:\/\/afsbio.com\/products\/recombinant-rat-tgfbr1-protein-his-tag-pder100074","provider":"AFSBio Inc.","version":"1.0","type":"link"}