{"product_id":"recombinant-rat-vegfr1-flt-1-protein-his-tagactive-pksr030362","title":"Recombinant Rat VEGFR1\/FLT-1 Protein (His Tag)(Active) - PKSR030362","description":"\u003cp\u003eRecombinant Rat VEGFR1\/FLT-1 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSR030362-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: VEGFR1; FLT-1\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: FLT1; Flt-1; Vegfr1\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Rat\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P53767\u003c\/p\u003e\n\n\u003cp\u003eAccession: P53767\u003c\/p\u003e\n\n\u003cp\u003eBackground: Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1\/PDGF receptor subfamily. VEGFR-1 \/ FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 \/ FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR-1 \/ FLT1 is not expressed in tumor cell lines. VEGFR-1 \/ FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis. EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells. VEGFR-1 \/ FLT1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand\/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized ratFLT1-His at 10 μg\/ml (100 μl\/well) can bind biotinylated mouse VEGFD-Fc with a linear range of 0.125-2.0 μg\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met1-Glu758\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 84 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 108-114 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107246080179,"sku":"PKSR030362-100","price":749.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_fd4733e4-e5a2-4528-bcab-5e8baaabef01.png?v=1709381881","url":"https:\/\/afsbio.com\/products\/recombinant-rat-vegfr1-flt-1-protein-his-tagactive-pksr030362","provider":"AFSBio Inc.","version":"1.0","type":"link"}