{"product_id":"recombinant-swine-il-4-proteinn-hisactive-pkss000004","title":"Recombinant Swine IL-4 protein(N-His)(active) - PKSS000004","description":"\u003cp\u003eRecombinant Swine IL-4 protein(N-His)(active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 5μg, 20μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSS000004-5, PKSS000004-20\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL-4\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: BCGF; BCDF; B-cell Stimulating Factor (BSF-1)\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Porcine\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eApplication: Cell culture\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q04745\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q04745\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation; survival and gene expression. IL-4 is produced by mast cells; T cells; and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells; characterized by their cytokine-secretion profile that includes secretion of IL-4; IL-5; IL-6; IL-10; and IL-13; which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measure by its ability to induce proliferation in TF-1 cells. The ED50 for this effect is \u0026lt; 0.6 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSequence: MGLTSQLIPTLVCLLACTSNFVHGHKCDITLQEIIKTLNILTARKNSCMELPVTDVFAAPENTTEKETFCRASTVLRHIYRHHTCMKSLLSGLDRNLSSMANMTCSVHEAKKSTLKDFLERLKTIMKEKYSKC\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 98 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 15.85 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"5μg","offer_id":43118187446451,"sku":"PKSS000004-5","price":277.2,"currency_code":"CAD","in_stock":true},{"title":"20μg","offer_id":43118187479219,"sku":"PKSS000004-20","price":693.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ee88793d-6c6f-432d-b331-440ea47d819f.png?v=1709637758","url":"https:\/\/afsbio.com\/products\/recombinant-swine-il-4-proteinn-hisactive-pkss000004","provider":"AFSBio Inc.","version":"1.0","type":"link"}