{"product_id":"recombinant-tgf-beta-1-monoclonal-antibody-e-ab-81441","title":"Recombinant TGF beta 1 Monoclonal Antibody - E-AB-81441","description":"\u003cp\u003eRecombinant TGF beta 1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-81441-50, E-AB-81441-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TGF beta 1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: TGF beta 1; TGFB; CED; LAP\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Rabbit Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone No.: R08-8B7\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P04202\u003c\/p\u003e\n\n\u003cp\u003eBackground: TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 300 μg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of mouse TGF beta 1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:1000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 44kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 44kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μL","offer_id":43149042745523,"sku":"E-AB-81441-50","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":43149042778291,"sku":"E-AB-81441-100","price":364.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_412f2299-421d-418b-88ff-70467ac0219d.png?v=1710339082","url":"https:\/\/afsbio.com\/products\/recombinant-tgf-beta-1-monoclonal-antibody-e-ab-81441","provider":"AFSBio Inc.","version":"1.0","type":"link"}