{"product_id":"recombinant-transcription-factor-7-like-2-monoclonal-antibody-e-ab-81487","title":"Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody - E-AB-81487","description":"Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: E-AB-81487-50, E-AB-81487-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: Transcription Factor 7 Like 2\n\nTarget Synonym: TCF7L2; HMG box transcription factor 4; HTCF-4; T-cell factor-4 variant X2; T-cell factor 4; Transcription factor 7-like 2; TCF-4\n\nConjugation: Unconjugated\n\nHost: Rabbit\n\nSpecies Reactivity: Human\n\nApplication: WB, IHC-P\n\nIsotype: IgG\n\nClonality: Rabbit Monoclonal\n\nClone No.: R09-1D1\n\nUNIProt ID: Q9NQB0\n\nBackground: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2\/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.\n\nConcentration: 300 μg\/mL\n\nImmunogen: A synthetic peptide of human TCF-4\n\nBuffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein\n\nPurification Method: Affinity Purified\n\nDilution: WB 1:500-1:1000 IHC 1:50-1:100\n\nCalculated MW: 68kDa\n\nObserved MW: 68kDa\n\nStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\n\nShipping: Ice bag\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"50μL","offer_id":43149043204275,"sku":"E-AB-81487-50","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":43149043237043,"sku":"E-AB-81487-100","price":364.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_eb8ac43e-929d-4bbc-b1f4-e622dda37058.png?v=1710339099","url":"https:\/\/afsbio.com\/products\/recombinant-transcription-factor-7-like-2-monoclonal-antibody-e-ab-81487","provider":"AFSBio Inc.","version":"1.0","type":"link"}