{"product_id":"repac-rabbit-polyclonal-antibody-es8099","title":"Repac Rabbit Polyclonal Antibody - ES8099","description":"\u003cp\u003eRepac Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8099-50, ES8099-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Members of the RAS (see HRAS, MIM 190020) subfamily of GTPases function in signal transduction as GTP\/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: RAPGEF5, GFR, KIAA0277, MRGEF, Rap guanine nucleotide exchange factor 5, Guanine nucleotide exchange factor for Rap1, M-Ras-regulated Rap GEF, MR-GEF, Related to Epac, Repac\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human RAPGEF5. AA range:431-480\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Repac\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Repac Polyclonal Antibody detects endogenous levels of Repac protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed with highest levels in brain,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 60kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Ras signaling pathway, Rap1 signaling pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS\/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation\u003cbr\u003e\nSimilarity: Contains 1 N-terminal Ras-GEF domain\u003cbr\u003e\nSimilarity: Contains 1 Ras-GEF domain\u003cbr\u003e\nTissue Specificity: Widely expressed with highest levels in brain\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Nucleus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: RAPGEF5\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Rap guanine nucleotide exchange factor 5\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 217944\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8C0Q9\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 362799\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P83900\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313788539059,"sku":"ES8099-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313788571827,"sku":"ES8099-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/repac-rabbit-polyclonal-antibody-es8099","provider":"AFSBio Inc.","version":"1.0","type":"link"}