{"product_id":"rev-erbα-phospho-ser55-59-rabbit-pab-es13420","title":"Rev-erbα (phospho-Ser55\/59) rabbit pAb - ES13420","description":"\u003cp\u003eRev-erbα (phospho-Ser55\/59) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES13420-50, ES13420-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthesized phosho peptide around human Rev-erbα (Ser55 and 59)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 67kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 9572\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P20393\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. Localizes predominantly to the nucleus at ZT8 whereas it is cytoplasmic at ZT20. Phosphorylation by CSNK1E enhances its cytoplasmic localization.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202403983539,"sku":"ES13420-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202404016307,"sku":"ES13420-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_ef64eccc-ef9f-444a-985e-5b56989de6dd.png?v=1767128437","url":"https:\/\/afsbio.com\/products\/rev-erb%ce%b1-phospho-ser55-59-rabbit-pab-es13420","provider":"AFSBio Inc.","version":"1.0","type":"link"}