{"product_id":"rfa2-monoclonal-antibody-bt-mca2782","title":"RFA2 Monoclonal Antibody - BT-MCA2782","description":"\u003cp\u003eRFA2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2782-50, BT-MCA2782-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide\/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: RFA2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2C5B6\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1,kappa\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: RFA2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human RFA2 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 29kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P15927\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: RP-A p34, RPA2, REPA2, RPA32, RPA34\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6118\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238516613299,"sku":"BT-MCA2782-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238516646067,"sku":"BT-MCA2782-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_468e7ac1-06a1-440e-a8f4-7e2b0c129359.png?v=1769382004","url":"https:\/\/afsbio.com\/products\/rfa2-monoclonal-antibody-bt-mca2782","provider":"AFSBio Inc.","version":"1.0","type":"link"}