{"product_id":"rfwd3-rabbit-pab-es6711","title":"RFWD3 rabbit pAb - ES6711","description":"\u003cp\u003eRFWD3 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6711-50, ES6711-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 RING-type zinc finger., similarity:Contains 3 WD repeats.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: RFWD3; RNF201; E3 ubiquitin-protein ligase RFWD3; RING finger and WD repeat domain-containing protein 3; RING finger protein 201\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human RFWD3. AA range:374-423\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 85kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 55159\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q6PCD5\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Nucleus, PML body. Cytoplasm. In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies (PubMed:21558276). In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair (PubMed:21504906, PubMed:28575657). This recruitment depends upon RPA2 (PubMed:21504906).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202310693043,"sku":"ES6711-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202310725811,"sku":"ES6711-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_e8e8dae0-3929-48dc-98c9-914e0e42e321.png?v=1767126282","url":"https:\/\/afsbio.com\/products\/rfwd3-rabbit-pab-es6711","provider":"AFSBio Inc.","version":"1.0","type":"link"}