{"product_id":"rgma-rabbit-monoclonal-antibody-bs41370","title":"RGMA Rabbit Monoclonal Antibody - BS41370","description":"\u003cp\u003eRGMA Rabbit Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS41370-50, BS41370-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Member of the repμlsive guidance molecμle (RGM) family that performs several functions in the developing and adμlt nervous system. Regμlates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1\/neogenin induces activation of RHOA-ROCK1\/Rho-kinase signaling pathway through UNC5B-ARHGEF12\/LARG-PTK2\/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1\/neogenin leads to HRAS inactivation by influencing HRAS-PTK2\/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human Mouse Rat\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC\/IF\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Repμlsive guidance molecμle A, RGM, RGM domain family member A, RGMA,\u003c\/p\u003e \n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthesized peptide derived from human RGMA\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500~1:2000 ICC\/IF 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: Affinity-chromatography\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: RGMA Antibody detects endogenous levels of total RGMA\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 37kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q96B86\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45937055891635,"sku":"BS41370-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45937055924403,"sku":"BS41370-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image.jpg?v=1788296056","url":"https:\/\/afsbio.com\/products\/rgma-rabbit-monoclonal-antibody-bs41370","provider":"AFSBio Inc.","version":"1.0","type":"link"}