{"product_id":"rgrf1-polyclonal-antibody-bt-ap13708","title":"RGRF1 Polyclonal Antibody - BT-AP13708","description":"\u003cp\u003eRGRF1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP13708-20, BT-AP13708-50, BT-AP13708-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: RASGRF1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Ras-specific guanine nucleotide-releasing factor 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13972; Mouse: P27671; Rat: P28818\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Ras-specific guanine nucleotide-releasing factor 1;Ras-GRF1;Guanine nucleotide-releasing protein;GNRP;Ras-specific nucleotide exchange factor CDC25\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5923\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239315136691,"sku":"BT-AP13708-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239315169459,"sku":"BT-AP13708-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239315202227,"sku":"BT-AP13708-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_19a62f03-3a90-46ef-9aca-22b36f20b51f.png?v=1769392957","url":"https:\/\/afsbio.com\/products\/rgrf1-polyclonal-antibody-bt-ap13708","provider":"AFSBio Inc.","version":"1.0","type":"link"}