{"product_id":"rip-rabbit-polyclonal-antibody-es13391","title":"RIP Rabbit Polyclonal Antibody - ES13391","description":"\u003cp\u003eRIP Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES13391-50, ES13391-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA, IHC\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human RIP AA range: 117-167\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: RIP\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of RIP at Human\/Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed, Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 24kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism\u003cbr\u003e\nPTM: Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues\u003cbr\u003e\nSimilarity: Contains 1 RIP-type zinc finger\u003cbr\u003e\nSubcellular Location: Only nuclear, localizes to PML body\u003cbr\u003e\nSubunit: Interacts with the RPA1 subunit of RPA complex\u003cbr\u003e\nTissue Specificity: Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Isoform 1]: Cytoplasm Nucleus, [Isoform 2]: Nucleus, PML body\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: RPAIN RIP\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: RIP\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 69723\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9CWY9\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 287463\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q4G2Y1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315105124531,"sku":"ES13391-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315105157299,"sku":"ES13391-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/rip-rabbit-polyclonal-antibody-es13391","provider":"AFSBio Inc.","version":"1.0","type":"link"}