{"product_id":"ripk1-polyclonal-antibody-bt-ap13817","title":"RIPK1 Polyclonal Antibody - BT-AP13817","description":"\u003cp\u003eRIPK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP13817-20, BT-AP13817-50, BT-AP13817-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction.,Belongs to the protein kinase superfamily. TKL Ser\/Thr protein kinase family.,Contains 1 death domain.,Contains 1 protein kinase domain.,subunit:Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN), EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS\/IPS1.,\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Cell biology; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: RIPK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Receptor-interacting serine\/threonine-protein kinase 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13546; Mouse: Q60855\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Receptor-interacting serine\/threonine-protein kinase 1;EC 2.7.11.1;Cell death protein RIP;Receptor-interacting protein 1;RIP-1;Serine\/threonine-protein kinase RIP\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8737\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239319330995,"sku":"BT-AP13817-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239319363763,"sku":"BT-AP13817-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239319396531,"sku":"BT-AP13817-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_495f3cfb-8700-436f-8f6e-563f53da1541.png?v=1769393000","url":"https:\/\/afsbio.com\/products\/ripk1-polyclonal-antibody-bt-ap13817","provider":"AFSBio Inc.","version":"1.0","type":"link"}