{"product_id":"ripk3-rabbit-polyclonal-antibody-es10828","title":"RIPK3 Rabbit Polyclonal Antibody - ES10828","description":"\u003cp\u003eRIPK3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10828-50, ES10828-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine\/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: RIP3,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: RIPK3 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. ; [Isoform 3]: Expression is significantly increased in colon and lung cancers.\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 56kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Necroptosis, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, TNF signaling pathway, Salmonella infection\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein. Promotes apoptosis. PTM: Autophosphorylated. Similarity: Belongs to the protein kinase superfamily. TKL Ser\/Thr protein kinase family. Similarity: Contains 1 protein kinase domain. Subunit: Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. Tissue Specificity: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Cytoplasm, cytosol Nucleus Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: RIPK3, RIP3\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Receptor-interacting serine\/threonine-protein kinase 3, EC 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 11035\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: Q9Y572\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9QZL0\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q9Z2P5\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825499463859,"sku":"ES10828-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825499496627,"sku":"ES10828-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/ripk3-rabbit-polyclonal-antibody-es10828","provider":"AFSBio Inc.","version":"1.0","type":"link"}