
U1 snRNP antigen
mRNA RefSeq: NM_001035065 NM_001034476 NM_001076334 NM_001046039 NM_001076046
Protein RefSeq: NP_001030237 NP_001029648 NP_001069802 NP_001039504 NP_001069514
Source: Calf Thymus
Catalogue Number: ATR01-02
Product Information
The snRNPs are a group of nuclear particles comprised of several polypeptides associated with a small nuclear RNA molecule. The most abundant snRNPs are involved in pre-mRNA-splicing. At least 13 different snRNAs have been identified in mammalian cells. Whereas autoantibodies directed against Sm are able to precipitate a wide range of snRNAs, RNP autoantibodies are only able to precipitate one particular type, referred to as U1snRNA.
Anti-RNP antibodies react with the U1 snRNP-specific polypeptides (68K, A and C antigens) whereas anti-Sm antibodies react with polypeptides associated with U1, U2, U5 and U4/U6 snRNAs (B,B', D, E, F and G antigens). While the 68K polypeptide constitutes the major MCTD RNP autoantigen, the major Sm autoantigen is represented by the D polypeptide.
The RNP 68K (present as a 33/35K doublet), RNP A and Sm D polypeptides represent the most abundant components of AROTEC's RNP/Sm antigen. Other snRNP subunits (RNP-C) are also detectable. Human Sm D1, D2 and D3 are identical to the bovine sequences indicating that the antigens are highly conserved across mammalian species.
Clinical Indications
Mixed connective tissue disease
Systemic Lupus Erythematosus
Various overlapping syndromes
MSDS
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