{"product_id":"rock-1-polyclonal-antibody-bt-ap07968","title":"Rock-1 Polyclonal Antibody - BT-AP07968","description":"\u003cp\u003eRock-1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP07968-20, BT-AP07968-50, BT-AP07968-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: ROCK1 encodes a protein serine\/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ROCK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Rock-1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 158175\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13464; Mouse: P70335; Rat: Q63644\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 6093; Mouse: 19877; Rat: 81762\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239889952947,"sku":"BT-AP07968-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239889985715,"sku":"BT-AP07968-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239890018483,"sku":"BT-AP07968-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_de0ccc5f-ba7a-4644-bf97-5eb1a2406760.png?v=1769400515","url":"https:\/\/afsbio.com\/products\/rock-1-polyclonal-antibody-bt-ap07968","provider":"AFSBio Inc.","version":"1.0","type":"link"}