{"product_id":"rpa-p32-phospho-ser33-rabbit-pab-es1439","title":"RPA p32 (phospho Ser33) rabbit pAb - ES1439","description":"\u003cp\u003eRPA p32 (phospho Ser33) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1439-50, ES1439-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions., PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC\/DNA-PK in the presence of Ku and DNA, and by CDC2., subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage., subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3\/RBT1. Interacts with TIPIN.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: RPA2; REPA2; RPA32; RPA34; Replication protein A 32 kDa subunit; RP-A p32; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human RFA2 around the phosphorylation site of Ser33. AA range:1-50\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 32kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 6118\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P15927\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Nucleus, PML body. Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202014175411,"sku":"ES1439-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202014208179,"sku":"ES1439-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_73184ef3-64e6-4c7e-b59b-75cb0591da1f.png?v=1767119949","url":"https:\/\/afsbio.com\/products\/rpa-p32-phospho-ser33-rabbit-pab-es1439","provider":"AFSBio Inc.","version":"1.0","type":"link"}