{"product_id":"rraga-polyclonal-antibody-e-ab-91050","title":"RRAGA Polyclonal Antibody - E-AB-91050","description":"\u003cp\u003eRRAGA Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-91050-60, E-AB-91050-120, E-AB-91050-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: RRAGA\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: RRAGA; FIP-1; FIP1; RAGA\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Metabolism, Microbiology, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q7L523\u003c\/p\u003e\n\n\u003cp\u003eBackground: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1\/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human RRAGA\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 36kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 33KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146587996339,"sku":"E-AB-91050-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146588029107,"sku":"E-AB-91050-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146588061875,"sku":"E-AB-91050-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_50c1f43a-bf02-4236-9afa-08526ba170c3.png?v=1710297924","url":"https:\/\/afsbio.com\/products\/rraga-polyclonal-antibody-e-ab-91050","provider":"AFSBio Inc.","version":"1.0","type":"link"}