{"product_id":"rtn3-polyclonal-antibody-e-ab-66432","title":"RTN3 Polyclonal Antibody - E-AB-66432","description":"\u003cp\u003eRTN3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-66432-60, E-AB-66432-120, E-AB-66432-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: RTN3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: RTN3; ASYIP; HAP; NSPL2; NSPLII; RTN3-A1\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O95197\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human RTN3 (NP_006045.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 23kDa\/25kDa\/26kDa\/27kDa\/100kDa\/110kDa\/112kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 26kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148669223091,"sku":"E-AB-66432-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148669255859,"sku":"E-AB-66432-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148669288627,"sku":"E-AB-66432-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_126e58f5-3c2f-4853-98a4-8e6e1a927f61.png?v=1710327696","url":"https:\/\/afsbio.com\/products\/rtn3-polyclonal-antibody-e-ab-66432","provider":"AFSBio Inc.","version":"1.0","type":"link"}