{"product_id":"rubic-rabbit-pab-es13314","title":"RUBIC rabbit pAb - ES13314","description":"\u003cp\u003eRUBIC rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES13314-50, ES13314-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: Run domain Beclin-1 interacting and cystein-rich containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human RUBIC AA range: 868-918\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 105kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 9711\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q92622\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Late endosome. Lysosome. Early endosome. Predominantly located in late endosomes\/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202403721395,"sku":"ES13314-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202403754163,"sku":"ES13314-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_107e04f0-5473-4760-b4c6-eea14cd8b129.png?v=1767128429","url":"https:\/\/afsbio.com\/products\/rubic-rabbit-pab-es13314","provider":"AFSBio Inc.","version":"1.0","type":"link"}