{"product_id":"runx1t1-polyclonal-antibody-e-ab-67119","title":"RUNX1T1 Polyclonal Antibody - E-AB-67119","description":"\u003cp\u003eRUNX1T1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-67119-60, E-AB-67119-120, E-AB-67119-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: RUNX1T1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: RUNX1T1; AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q06455\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor\/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human RUNX1T1 (NP_783554.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:200-1:1000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 44kDa\/48kDa\/63kDa\/64kDa\/67kDa\/68kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 67kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146437689523,"sku":"E-AB-67119-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146437722291,"sku":"E-AB-67119-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146437755059,"sku":"E-AB-67119-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_42998ff6-0ea7-4ea9-b6a4-8921c7ccdf2e.png?v=1710295543","url":"https:\/\/afsbio.com\/products\/runx1t1-polyclonal-antibody-e-ab-67119","provider":"AFSBio Inc.","version":"1.0","type":"link"}