{"product_id":"runx3-polyclonal-antibody-bt-ap08062","title":"RUNX3 Polyclonal Antibody - BT-AP08062","description":"\u003cp\u003eRUNX3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP08062-20, BT-AP08062-50, BT-AP08062-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: RUNX3 (runt related transcription factor 3) encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and RUNX3 is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: RUNX3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: RUNX3 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 44356\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13761; Mouse: Q64131\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: RUNX3; AML2; CBFA3; PEBP2A3; Runt-related transcription factor 3; Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; CBF-alpha-3; Oncogene AML-2; Polyomavirus enhancer-binding prot\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 864\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239893754035,"sku":"BT-AP08062-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239893786803,"sku":"BT-AP08062-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239893819571,"sku":"BT-AP08062-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_e2b49037-923a-483f-baaf-b39e9a6be7cb.png?v=1769400573","url":"https:\/\/afsbio.com\/products\/runx3-polyclonal-antibody-bt-ap08062","provider":"AFSBio Inc.","version":"1.0","type":"link"}