{"product_id":"ruvb2-rabbit-polyclonal-antibody-es13304","title":"RUVB2 Rabbit Polyclonal Antibody - ES13304","description":"\u003cp\u003eRUVB2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES13304-50, ES13304-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB\/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human RUVB2 AA range: 7-57\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: RUVB2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of RUVB2 at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitously expressed, Highly expressed in testis and thymus,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 51kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Domain: The C-terminal domain is required for association with ATF2\u003cbr\u003e\nFunction: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RU\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus matrix Nucleus, nucleoplasm Cytoplasm Membrane Dynein axonemal particle Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol Although it is also present in the cytoplasm and associated with the cell membranes\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: RUVBL2 INO80J TIP48 TIP49B CGI-46\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: RUVB2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 20174\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9WTM5\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315100405939,"sku":"ES13304-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315100438707,"sku":"ES13304-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/ruvb2-rabbit-polyclonal-antibody-es13304","provider":"AFSBio Inc.","version":"1.0","type":"link"}