{"product_id":"ryr2-polyclonal-antibody-bs91191","title":"RYR2 Polyclonal Antibody-BS91191","description":"\u003cp\u003eRYR2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91191-50, BS91191-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q92736(Human) E9Q401(Mouse) B0LPN4(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC IHC FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500\u003cbr\u003e\nICC:1:50-1:100\u003cbr\u003e\nIHC:1:50-1:200\u003cbr\u003e\nFC:1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Peptide affinity purified.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: RYR2 polyclonal antibody detects endogenous levels of RYR2 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 565 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Dot blot analysis of anti-RYR2 immunization peptide on PVDF. 1ug, 2ug and 4ug peptides were given in this test. Anti-RYR2 antibody was diluted with 1\/500., ICC staining RYR2 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: RYR-2, RyR2, hRYR-2, RYR2, Arrhythmogenic right ventricular dysplasia 2, ARVC2, ARVD2, Brain ryanodine receptor calcium release channel, Brain type ryanodine receptor, Cardiac muscle ryanodine receptor calcium release channel, Cardiac muscle type ryanodine receptor, CCO, Central core disease of muscle, HBRR, hRYR 2, hRYR2, MHS, MHS1, Ryanodine receptor 1 (skeletal), Ryanodine receptor 1, Ryanodine receptor 2 (cardiac), Ryanodine receptor 2, Ryanodine receptor 3, Ryanodine receptor type1, RYDR, RYR 1, RYR 2, RYR 3, RYR, RYR-1, RyR1, RYR1, RYR2, RYR3, Sarcoplasmic reticulum calcium release channel, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle type ryanodine receptor, Skeletal muscle-type ryanodine receptor, SKRR, Type 1 like ryanodine receptor, Type 1 ryanodine receptor, VTSIP,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthetic peptide within human RYR2 aa 1450-1550.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984621375667,"sku":"BS91191-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984621408435,"sku":"BS91191-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_8ddf6a04-ba12-4c83-9138-37d5e7b7453c.jpg?v=1705919533","url":"https:\/\/afsbio.com\/products\/ryr2-polyclonal-antibody-bs91191","provider":"AFSBio Inc.","version":"1.0","type":"link"}