{"product_id":"s100a4-polyclonal-antibody-e-ab-40458","title":"S100A4 Polyclonal Antibody - E-AB-40458","description":"\u003cp\u003eS100A4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-40458-60, E-AB-40458-120, E-AB-40458-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: S100A4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 18A2; 42A; calcium Placental protein; Calvasculin; CAPL; Fibroblast specific protein 1; FSP1; Leukemia multidrug resistance associated protein; Malignant transformation suppression 1; Metastasin; MTS1; OTTHUMP00000015467; OTTHUMP00000015468; P9KA; PEL98; Placental calcium-binding protein; Protein Mts1; Protein S100 A4; S100 calcium binding protein A4; S100a4\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular, Signal Transduction, Cancer\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P26447\u003c\/p\u003e\n\n\u003cp\u003eBackground: S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells and the extracellular space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo. It is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis. Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.2mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Human Protein S100-A4 protein\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen Affinity Purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB:1:500-1000 IHC 1:100-1:400\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 11kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 11kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146032316595,"sku":"E-AB-40458-60","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146032349363,"sku":"E-AB-40458-120","price":322.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146032382131,"sku":"E-AB-40458-200","price":532.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_95b12f25-cb6f-43a3-9bf8-dc8247c0bfc1.png?v=1710290181","url":"https:\/\/afsbio.com\/products\/s100a4-polyclonal-antibody-e-ab-40458","provider":"AFSBio Inc.","version":"1.0","type":"link"}