{"product_id":"sac2-rabbit-polyclonal-antibody-es13217","title":"SAC2 Rabbit Polyclonal Antibody - ES13217","description":"\u003cp\u003eSAC2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES13217-50, ES13217-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human SAC2 AA range: 1006-1056\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: SAC2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of SAC2 at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitous (PubMed:11274189), Highly expressed in brain (PubMed:26203138),\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 125kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT\/GSK3B pathway by decreasing AKT and GSK3B phosphorylation\u003cbr\u003e\nMiscellaneous: Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase\u003cbr\u003e\nSimilarity: Contains 1 SAC domain\u003cbr\u003e\nTissue Specificity: Ubiquitous\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Membrane, clathrin-coated pit Early endosome Recycling endosome Also found on macropinosomes\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: INPP5F KIAA0966 SAC2 MSTP007 MSTP047\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: SAC2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 101490\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8CDA1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315075993779,"sku":"ES13217-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315076026547,"sku":"ES13217-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/sac2-rabbit-polyclonal-antibody-es13217","provider":"AFSBio Inc.","version":"1.0","type":"link"}