{"product_id":"sardh-rabbit-polyclonal-antibody-es13199","title":"SARDH Rabbit Polyclonal Antibody - ES13199","description":"\u003cp\u003eSARDH Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES13199-50, ES13199-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA, IHC\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human SARDH AA range: 279-329\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: SARDH\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of SARDH at Human\/Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in pancreas, liver and kidney,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 101kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Glycine, serine and threonine metabolism, Metabolic pathways\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: Sarcosine + acceptor + H(2)O = glycine + formaldehyde + reduced acceptor\u003cbr\u003e\nCofactor: Binds 1 FAD covalently per monomer\u003cbr\u003e\nDisease: Defects in SARDH are a ause of sarcosinemia [MIM: 268900]. Sarcosinemia is a metabolic disorder characterized by an increased concentration of sarcosine in plasma and urine due to sarcosine dehydrogenase deficiency. Prevalence has been estimated at 1: 28'000 to 1: 350'000 in newborn screening programs. Sarcosinemia is most probably a benign condition without significant clinical problems. It is transmitted in an autosomal recessive manner\u003cbr\u003e\nPathway: Amine and polyamine degradation, sarcosine degradation, formaldehyde and glycine from sarcosine: step 1\/1\u003cbr\u003e\nSimilarity: Belongs to the gcvT family\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Mitochondrion matrix\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: SARDH DMGDHL1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: SARDH\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 192166\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q99LB7\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 114123\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q64380\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315074060467,"sku":"ES13199-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315074093235,"sku":"ES13199-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/sardh-rabbit-polyclonal-antibody-es13199","provider":"AFSBio Inc.","version":"1.0","type":"link"}