{"product_id":"sarm1-polyclonal-antibody-bt-ap14045","title":"SARM1 Polyclonal Antibody - BT-AP14045","description":"\u003cp\u003eSARM1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14045-20, BT-AP14045-50, BT-AP14045-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,Involved in innate immnune response. Acts as a negative regulator of TICAM1\/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1\/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,Contains 1 TIR domain.,Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1\/TRIF and thereby interferes with TICAM1\/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.,\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology; Immunology; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SARM1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Sterile alpha and TIR motif-containing protein 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q6SZW1; Mouse: Q6PDS3\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Sterile alpha and TIR motif-containing protein 1;Sterile alpha and Armadillo repeat protein;Sterile alpha motif domain-containing protein 2;SAM domain-containing protein 2;Tir-1 homolog\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 23098\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239337222323,"sku":"BT-AP14045-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239337255091,"sku":"BT-AP14045-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239337287859,"sku":"BT-AP14045-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_877dd855-6ca1-4492-8afa-1b282f4e2e1d.png?v=1769393218","url":"https:\/\/afsbio.com\/products\/sarm1-polyclonal-antibody-bt-ap14045","provider":"AFSBio Inc.","version":"1.0","type":"link"}