{"product_id":"sarm1-polyclonal-antibody-e-ab-92292","title":"SARM1 Polyclonal Antibody - E-AB-92292","description":"\u003cp\u003eSARM1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92292-60, E-AB-92292-120, E-AB-92292-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SARM1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: SARM; HsTIR; SAMD2; hSARM1; MyD88-5\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IP\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q6SZW1\u003c\/p\u003e\n\n\u003cp\u003eBackground: NAD(+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide; NAD(+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+, but not other NAD(+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1\/TRIF- and MYD88-dependent activation of JUN\/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14\/p38.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human SARM1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IP 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 79kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 73KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148873793715,"sku":"E-AB-92292-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148873826483,"sku":"E-AB-92292-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148873859251,"sku":"E-AB-92292-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a9dcf6f0-62ce-463f-a0c7-6820eb3c69b3.png?v=1710331203","url":"https:\/\/afsbio.com\/products\/sarm1-polyclonal-antibody-e-ab-92292","provider":"AFSBio Inc.","version":"1.0","type":"link"}