{"product_id":"sars-cov-2-spike-s1-rabbit-pab-a20604","title":"SARS-CoV-2 Spike S1 Rabbit pAb - A20604","description":"\u003cp\u003eSARS-CoV-2 Spike S1 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A20604-20, A20604-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: SARS-CoV\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 139kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 200kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 1489668\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P59594\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: E2; SARS-CoV-2 Spike S1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: Spike S1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189378736307,"sku":"A20604-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189378769075,"sku":"A20604-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_4b7f857a-c053-4375-a79e-54d8ef0fe89b.png?v=1766425811","url":"https:\/\/afsbio.com\/products\/sars-cov-2-spike-s1-rabbit-pab-a20604","provider":"AFSBio Inc.","version":"1.0","type":"link"}