{"product_id":"sav1-polyclonal-antibody-e-ab-62507","title":"SAV1 Polyclonal Antibody - E-AB-62507","description":"\u003cp\u003eSAV1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-62507-60, E-AB-62507-120, E-AB-62507-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SAV1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: SAV1; SAV; WW45; WWP4\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9H4B6\u003c\/p\u003e\n\n\u003cp\u003eBackground: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human SAV1 (NP_068590.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:1000-1:4000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 44kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 45kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146247667891,"sku":"E-AB-62507-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146247700659,"sku":"E-AB-62507-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146247733427,"sku":"E-AB-62507-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a215c3c0-df85-41a8-b1a5-ccac29e8108e.png?v=1710292346","url":"https:\/\/afsbio.com\/products\/sav1-polyclonal-antibody-e-ab-62507","provider":"AFSBio Inc.","version":"1.0","type":"link"}