{"product_id":"sc5a5-rabbit-polyclonal-antibody-es10287","title":"SC5A5 Rabbit Polyclonal Antibody - ES10287","description":"\u003cp\u003eSC5A5 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10287-50, ES10287-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: SC5A5,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: SC5A5 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 70kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Thyroid hormone synthesis\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in SLC5A5 are the cause of congenital hypothyroidism due to dyshormonogenesis type 1 (CHDH1) [MIM:274400]. CHDH1 is characterized by an inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Mediates iodide uptake in the thyroid gland. Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Tissue Specificity: Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Membrane, Multi-pass membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: SLC5A5, NIS\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Sodium\/iodide cotransporter, Na(+ \/I(- cotransporter, Sodium-iodide symporter, Na(+ \/I(- symporter, Solute carrier family 5 member 5\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 6528\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: Q92911\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q99PN0\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q63008\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825499201715,"sku":"ES10287-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825499234483,"sku":"ES10287-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/sc5a5-rabbit-polyclonal-antibody-es10287","provider":"AFSBio Inc.","version":"1.0","type":"link"}