{"product_id":"scaf8-polyclonal-antibody-e-ab-92158","title":"SCAF8 Polyclonal Antibody - E-AB-92158","description":"\u003cp\u003eSCAF8 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92158-60, E-AB-92158-120, E-AB-92158-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SCAF8\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: SCAF8; RBM16\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9UPN6\u003c\/p\u003e\n\n\u003cp\u003eBackground: Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD of the largest RNA polymerase II subunit (POLR2A, and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human SCAF8\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:1000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 140kDa\/147kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 170KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146627776691,"sku":"E-AB-92158-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146627809459,"sku":"E-AB-92158-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146627842227,"sku":"E-AB-92158-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d4e7f39c-a002-4109-ba53-6cc48532d526.png?v=1710298786","url":"https:\/\/afsbio.com\/products\/scaf8-polyclonal-antibody-e-ab-92158","provider":"AFSBio Inc.","version":"1.0","type":"link"}