{"product_id":"sclerostin-polyclonal-antibody-bt-ap08158","title":"Sclerostin Polyclonal Antibody - BT-AP08158","description":"\u003cp\u003eSclerostin Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP08158-20, BT-AP08158-50, BT-AP08158-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Sclerostin (SOST) is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in SOST are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of SOST, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SOST\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Sclerostin Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 24031\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9BQB4; Mouse: Q99P68\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SOST; Sclerostin\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 50964\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239897161907,"sku":"BT-AP08158-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239897194675,"sku":"BT-AP08158-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239897227443,"sku":"BT-AP08158-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_9f4bb43e-3ba4-4877-907a-4ae8b3e68b83.png?v=1769400622","url":"https:\/\/afsbio.com\/products\/sclerostin-polyclonal-antibody-bt-ap08158","provider":"AFSBio Inc.","version":"1.0","type":"link"}