{"product_id":"sco1-rabbit-polyclonal-antibody-es13182","title":"SCO1 Rabbit Polyclonal Antibody - ES13182","description":"\u003cp\u003eSCO1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES13182-50, ES13182-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human SCO1 AA range: 223-273\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: SCO1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of SCO1 at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 33kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in SCO1 are a cause of cytochrome c oxidase deficiency (COX deficiency) [MIM: 220110]. COX deficiency is a clinically heterogeneous disorder. The clinical features are ranging from isolated myopathy to severe multisystem disease, with onset from infancy to adulthood\u003cbr\u003e\nFunction: Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX\u003cbr\u003e\nSimilarity: Belongs to the SCO1\/2 family\u003cbr\u003e\nSubunit: Homodimer\u003cbr\u003e\nTissue Specificity: Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Mitochondrion Mitochondrion inner membrane, Single-pass membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: SCO1 SCOD1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: SCO1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 52892\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q5SUC9\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315071733939,"sku":"ES13182-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315071766707,"sku":"ES13182-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/sco1-rabbit-polyclonal-antibody-es13182","provider":"AFSBio Inc.","version":"1.0","type":"link"}