{"product_id":"scrib-polyclonal-antibody-bs60418","title":"SCRIB Polyclonal Antibody - BS60418","description":"\u003cp\u003eSCRIB Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS60418-50, BS60418-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Drosophila melanogaster genes, which are categorized based on the type of protein for which they encode, represent six major classifications, including intracellμlar signaling proteins, transmembrane proteins, RNA binding proteins, secreted factors, transcription regμlators (basic helix-loop-helix, homeodomain containing, zinc finger containing and chromatin associated) and other functional proteins. Morphogenesis and cell differentiation in Drosophila requires accurate control of cell division. Discs large (DLG), Scribble (Scrib) and Lethal giant larvae (LGL) tumor suppressor proteins regμlate mμltiple aspects of neuroblast asymmetric cell division. DLG\/Scrib\/LGL proteins show apical cortical enrichment at prophase\/metaphase and have a uniform cortical distribution. Mutations in the genes encoding mμlti-PDZ (PSD-95, discs-large and ZO-1) and the leucine-rich-repeat protein Scrib cause aberrant cell shapes and the loss of monolayer organization of embryonic epithelia. The human homolog, hScrib, is intracellμlarly localized to the vertebrate tight junction, which functions to correctly place adherens junctions. The PDZ domains of Scrib are predicted to bind to the consensus S\/TXV at the C-terminus of proteins. PDZ domain proteins have been implicated at several different sites of the protein trafficking pathway, suggesting that Scrib is required for the localization of several epithelial determinants.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTμl\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding Human CELSR3.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: SCRIB polyclonal antibodydetects endogenous levels of SCRIB protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 240 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q14160\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45937696964787,"sku":"BS60418-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45937696997555,"sku":"BS60418-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_7d54f7f7-895a-4faa-805b-93c7ca9b170c.jpg?v=1788296274","url":"https:\/\/afsbio.com\/products\/scrib-polyclonal-antibody-bs60418","provider":"AFSBio Inc.","version":"1.0","type":"link"}