{"product_id":"sdcbp-syntenin-mouse-monoclonal-antibody-mb4016","title":"SDCBP (Syntenin) Mouse Monoclonal Antibody - MB4016","description":"\u003cp\u003eSDCBP (Syntenin) Mouse Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 25μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB4016-25, MB4016-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Syntenin-1 (MDA9, SDCBP) is a member of the PDZ family of proteins, defined by the presence of a PDZ protein interaction domain. Syntenin-1, via its PDZ domain, functions as a scaffold adaptor protein that regμlates numerous signal transduction pathways, including FAK, Src, TGFβR1, EGFR, and IGF1R. Aberrantly elevated expression of syntenin-1 has been found in various cancers, and has been linked to growth and invasion of tumor cells. In the central nervous system, syntenin-1 has been shown to mediate neuron dendrite protrusion and spine formation through its interaction with syndecan and Rheb. Syntenin-1 is also a key component of the syndecan\/syntenin\/ALIX pathway which has been shown to directly contribute to the formation and internalization of exosomes.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Syntenin-1, Melanoma differentiation-associated protein 9 (MDA-9), Pro-TGF-alpha cytoplasmic domain-interacting protein 18 (TACIP18), Scaffold protein Pbp1, Syndecan-binding protein 1, SDCBP\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fμll length human recombinant protein of human SDCBP(NP_005616) produced in HEK293T cell.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500~2000, IHC 1:150\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG1\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 32 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: O00560\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"25μl","offer_id":45945962496179,"sku":"MB4016-25","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45945962528947,"sku":"MB4016-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/sdcbp-syntenin-mouse-monoclonal-antibody-mb4016","provider":"AFSBio Inc.","version":"1.0","type":"link"}