{"product_id":"sdhb-polyclonal-antibody-e-ab-63462","title":"SDHB Polyclonal Antibody - E-AB-63462","description":"\u003cp\u003eSDHB Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-63462-60, E-AB-63462-120, E-AB-63462-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SDHB\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: SDHB; CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Cell biology,Metabolism,Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P21912\u003c\/p\u003e\n\n\u003cp\u003eBackground: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human SDHB\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IF 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 31kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 32KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146288627891,"sku":"E-AB-63462-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146288660659,"sku":"E-AB-63462-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146288693427,"sku":"E-AB-63462-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_45f60491-c7b4-4a77-8f73-733d239b164f.png?v=1710293061","url":"https:\/\/afsbio.com\/products\/sdhb-polyclonal-antibody-e-ab-63462","provider":"AFSBio Inc.","version":"1.0","type":"link"}