{"product_id":"sek1-mkk4-phospho-thr261-rabbit-polyclonal-antibody-bt-ap12594","title":"SEK1\/MKK4 (Phospho-Thr261) Rabbit Polyclonal Antibody - BT-AP12594","description":"\u003cp\u003eSEK1\/MKK4 (Phospho-Thr261) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12594-20, BT-AP12594-50, BT-AP12594-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation| differentiation| transcription regulation| and development. They form a three-tiered signaling module composed of MAPKKKs| MAPKKs| and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MAP2K4\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: SEK1\/MKK4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P45985; Mouse: P47809\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SEK1\/MKK4;Thr261; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK\/ERK kinase 4; MEK 4; SAPK\/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 6416; Mouse: 26398\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239021404339,"sku":"BT-AP12594-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239021437107,"sku":"BT-AP12594-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239021469875,"sku":"BT-AP12594-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_63b7b833-01e2-4bda-99da-80faa56c178e.png?v=1769388027","url":"https:\/\/afsbio.com\/products\/sek1-mkk4-phospho-thr261-rabbit-polyclonal-antibody-bt-ap12594","provider":"AFSBio Inc.","version":"1.0","type":"link"}